Cattle Drive Casserole Recipe
If you’re craving a dish that combines hearty, comforting flavors with a fun twist, then the Cattle Drive Casserole is about to become your new favorite. This casserole brings together seasoned ground beef, vibrant bell peppers, a flaky biscuit crust, and a luscious creamy layer all baked to bubbling perfection. Every bite offers a delightful mix of textures and savory elements that feel like a warm hug on a plate. It’s an absolute crowd-pleaser that’s perfect for weeknight dinners or feeding a hungry family with minimal fuss.

Ingredients You’ll Need
The beauty of this recipe lies in its straightforward and familiar ingredients, each playing a vital role in crafting the layers of flavor and texture that make the Cattle Drive Casserole so irresistible. From the spiced beef to the creamy topping and cheesy finish, every ingredient is essential to bring this casserole to life.
- Lean Ground Beef: The protein-packed meaty base with rich flavor and satisfying texture.
- Red Bell Pepper: Adds a sweet crunch and beautiful color contrast.
- Yellow Onion: Brings a subtle sweetness and aroma when sautéed.
- Taco Seasoning Mix: Provides a zesty, savory punch that elevates the beef.
- Biscuit Mix (like Bisquick): Forms a quick, fluffy crust that holds everything together.
- Water: Used to bind the biscuit mix into dough.
- Cooking Spray: Prevents sticking and allows easy serving.
- Sour Cream: Gives a tangy, creamy layer that balances spices.
- Mayonnaise: Adds moisture and richness for that luscious texture.
- Diced Green Chiles: Bring a mild heat and subtle smoky depth.
- Cheddar Cheese, Fiesta Blend: Melts beautifully, adding gooey, sharp goodness.
- Garlic Powder: Complements and deepens all the savory flavors.
- Salsa, Mild: Delivers bursts of fresh tomato flavor and brightness.
How to Make Cattle Drive Casserole
Step 1: Preheat and Cook the Beef
Begin by setting your oven to 350℉ to prepare for baking. Over medium-high heat, cook the lean ground beef in a skillet until it loses all pinkness, breaking it apart as it cooks. This step ensures the meat is evenly browned, which adds that essential savory backbone to your casserole. Once cooked, drain any excess fat to keep the dish from becoming greasy.
Step 2: Prepare the Biscuit Dough Base
While the beef cooks, mix the biscuit mix with water in a bowl, stirring until the dough is fully combined—hands work wonders here to get an even consistency. Press the dough into a greased 9×13-inch casserole dish, pushing it all the way to the edges. Bake the dough for about 5-8 minutes until it sets and gains a lovely light golden crust. This biscuit base will be the perfect sturdy yet tender foundation for your casserole.
Step 3: Sauté the Vegetables with Taco Seasoning
Once your beef is ready, toss in the chopped onion and red bell pepper. Cooking these veggies just a few minutes softens them and lets their natural sweetness come through, perfectly complementing the savory meat. Sprinkle in the taco seasoning and stir well, infusing the mix with a spicy, aromatic punch that screams comfort food at its best.
Step 4: Assemble the Layers
Spread the seasoned ground beef and vegetables evenly over the freshly baked biscuit crust. This layering ensures each bite is a well-rounded experience of textures and flavors—solid biscuit base, hearty beef, and vibrant veggies all in one.
Step 5: Mix and Spread the Creamy Layer
In a separate bowl, combine sour cream, mayonnaise, diced green chiles, ¾ cup of shredded cheese, and garlic powder. Stir until the mixture is smooth and creamy. Carefully spread this luscious layer over the meat, adding a cool, tangy contrast to the rich beef below. This step is where the casserole starts becoming memorable.
Step 6: Add Salsa and Final Cheese Topping
Dot spoonfuls of mild salsa across the creamy layer—you don’t need to spread it evenly, as those little pockets of salsa will add pops of fresh, zesty flavor. Sprinkle the remaining shredded cheese evenly on top, guaranteeing a bubbly, melted crown once baked.
Step 7: Bake to Perfection
Return the assembled casserole to the oven, uncovered, and bake for around 30 minutes. Look for a bubbling, golden top to signal that your Cattle Drive Casserole is ready to impress. This final baking melds all flavors together and creates the perfect casserole crust on top.
How to Serve Cattle Drive Casserole

Garnishes
To elevate your Cattle Drive Casserole even further, try garnishing with fresh chopped cilantro or green onions. A dollop of cool sour cream or a few slices of jalapeño on top can add an extra layer of creaminess or heat, ideal for customizing each serving to your mood or guest preferences.
Side Dishes
This casserole pairs beautifully with simple green salads or steamed veggies to balance out the richness of the dish. A side of Mexican rice or corn on the cob can also complement the southwestern flair while keeping the meal hearty and satisfying.
Creative Ways to Present
For a fun twist when entertaining, serve the Cattle Drive Casserole in individual ramekins or mini cast iron skillets. This not only looks charming but also guarantees each portion stays warm and bubbly till the last bite. You could even turn it into a layered dip for casual get-togethers—just scoop out the layers and serve with tortilla chips.
Make Ahead and Storage
Storing Leftovers
Any leftovers from your Cattle Drive Casserole can be stored in an airtight container in the refrigerator for up to 3 days. Make sure to cool it completely before sealing to maintain the best texture and flavor when you reheat it.
Freezing
This casserole freezes wonderfully. Wrap tightly with plastic wrap and then foil to prevent freezer burn, and store for up to 2 months. When ready to enjoy, thaw overnight in the refrigerator for the best results.
Reheating
Reheat individual portions in the microwave for about 2-3 minutes or until warmed through. If reheating the whole casserole, cover with foil and bake at 350℉ for 20-25 minutes until heated evenly and bubbly once again.
FAQs
Can I use a different type of meat for Cattle Drive Casserole?
Absolutely! While lean ground beef is traditional and adds great flavor, you can substitute ground turkey or chicken for a lighter version. Just adjust seasoning as needed to maintain rich taste.
Is there a vegetarian option for this casserole?
Yes! You can replace the meat with seasoned beans or a plant-based meat substitute. Add extra vegetables like mushrooms or zucchini to boost texture and protein.
Can I make the biscuit crust from scratch?
Definitely! If you prefer homemade biscuit dough, feel free to use your favorite recipe. Just make sure it’s sturdy enough to hold the layers without becoming soggy.
What kind of cheese works best for this casserole?
Cheddar Fiesta blend is great for flavor and melt, but you can experiment with Monterey Jack or Pepper Jack for a spicier kick or a smoother melt.
How spicy is the Cattle Drive Casserole?
This casserole is mildly spiced thanks to the taco seasoning and green chiles, but it’s easily customizable. Add hotter salsa or extra chiles if you love more heat.
Final Thoughts
If you’re looking for a dish that’s simple to prepare yet bursting with bold flavors and textures, the Cattle Drive Casserole should be at the top of your list. Its layers of seasoned beef, flaky biscuit base, and creamy cheesy topping make it a guaranteed winner at any dinner table. I can’t wait for you to try it and experience just how comforting and delicious this casserole truly is.
PrintCattle Drive Casserole Recipe
Cattle Drive Casserole is a hearty, flavorful dish combining seasoned ground beef, vegetables, and a cheesy sour cream layer baked atop a golden biscuit crust. This classic comfort meal is perfect for family dinners, offering a satisfying blend of textures and rich southwestern-inspired flavors.
- Prep Time: 15 minutes
- Cook Time: 45 minutes
- Total Time: 1 hour
- Yield: 8 servings 1x
- Category: Casserole
- Method: Baking, Sautéing
- Cuisine: American, Southwestern
- Diet: Low Salt
Ingredients
Meat & Vegetables
- 1.5 pounds Lean Ground Beef
- 1 Red Bell Pepper, seeded and chopped
- 1 Yellow Onion, chopped
Seasonings & Sauces
- 1 ounce Taco Seasoning Mix
- 1 teaspoon Garlic Powder
- ½ cup Salsa, mild
- 4 ounces Diced Green Chiles, drained
Dough
- 2 ½ cups Biscuit Mix (like Bisquick)
- 1 cup Water
- Cooking Spray (such as Pam), for greasing
Dairy & Cheese
- ½ cup Sour Cream
- ½ cup Mayonnaise
- 1 ½ cups Cheddar Cheese, Fiesta Blend, shredded, divided
Instructions
- Preheat the Oven: Set your oven to 350℉ to prepare for baking the biscuit crust and casserole later.
- Cook the Ground Beef: Heat a large skillet over medium-high heat. Add the ground beef and break it apart with a spoon. Cook, stirring occasionally, until the meat is fully browned and no longer pink. Drain excess fat from the skillet. While the beef cooks, you can begin preparing the biscuit dough.
- Prepare the Biscuit Dough: In a medium mixing bowl, combine the biscuit mix and water. Stir until well incorporated and knead lightly with your hands for thorough mixing. Grease a 9 x 13-inch casserole dish with cooking spray. Press the dough evenly into the dish, pushing it out to the edges. Bake in the preheated oven for 5 to 8 minutes, until the dough sets and turns lightly golden. Remove from oven and keep the oven on.
- Cook the Vegetables: To the skillet with cooked ground beef, add the chopped onion and red bell pepper. Cook for about 4 minutes until softened. Stir in the taco seasoning mix until evenly distributed, then remove the skillet from the heat.
- Assemble the Layers: Spread the cooked ground beef and vegetable mixture evenly over the pre-baked biscuit crust in the casserole dish.
- Prepare the Sour Cream Layer: In another medium bowl, combine sour cream, mayonnaise, drained diced green chiles, ¾ cup of the shredded cheddar cheese, and garlic powder. Mix well until smooth. Carefully spread this sour cream mixture evenly over the ground beef layer.
- Add Salsa and Cheese: Spoon small dollops of salsa across the sour cream layer, leaving them as little mounds without spreading. Finally, sprinkle the remaining ¾ cup shredded cheese evenly over the top for a cheesy finish.
- Bake: Return the assembled casserole to the oven, uncovered. Bake for 30 minutes or until the top is hot, bubbly, and cheese is melted and slightly golden. Remove from oven and let it cool slightly before serving.
Notes
- You can substitute the biscuit mix with homemade biscuit dough if desired.
- For added spice, use medium or hot salsa instead of mild.
- Serving with fresh cilantro or sliced jalapeños adds an extra fresh kick.
- To reduce fat, use low-fat sour cream and reduced-fat cheese.
- Leftovers store well in the refrigerator for up to 3 days and reheat nicely in the oven or microwave.
Nutrition
- Serving Size: 1 slice (about 1/8th of casserole)
- Calories: 420
- Sugar: 3g
- Sodium: 600mg
- Fat: 25g
- Saturated Fat: 10g
- Unsaturated Fat: 12g
- Trans Fat: 0.5g
- Carbohydrates: 25g
- Fiber: 2g
- Protein: 25g
- Cholesterol: 80mg
Keywords: cattle drive casserole, ground beef casserole, biscuit crust casserole, southwestern casserole, cheesy beef casserole